You have to assume a grand ends is achievable through some knowable means. I don't see any real reason to think this is the case, certainly not on any sort of a meaningful timeframe. And I think this is even less true when we consider the typical connotation of Machiavellianism, which is through 'evil' actions.

It's extremely difficult to think of any real achievements sustained on the back of Machiavellianism, but one can list essentially endless entities whose downfall was brought on precisely by such.